Crosstalk between the Tor and Gcn2 pathways in response to different stresses.
Identifieur interne : 000F02 ( Main/Exploration ); précédent : 000F01; suivant : 000F03Crosstalk between the Tor and Gcn2 pathways in response to different stresses.
Auteurs : Gro Elise R Dland [Norvège] ; Tonje Tveg Rd [Norvège] ; Erik Boye [Norvège] ; Beáta Grallert [Norvège]Source :
- Cell cycle (Georgetown, Tex.) [ 1551-4005 ] ; 2014.
Descripteurs français
- KwdFr :
- Acides aminés (métabolisme), Facteur-2 d'initiation eucaryote (métabolisme), Inanition (métabolisme), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Schizosaccharomyces pombe (métabolisme), Rayons ultraviolets (MeSH), Schizosaccharomyces (métabolisme), Sirolimus (pharmacologie), Stress oxydatif (MeSH), Stress physiologique (MeSH), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH).
- MESH :
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- métabolisme : Acides aminés, Facteur-2 d'initiation eucaryote, Inanition, Protein-Serine-Threonine Kinases, Protéines de Schizosaccharomyces pombe, Schizosaccharomyces, Sérine-thréonine kinases TOR.
- pharmacologie : Sirolimus.
- Phosphorylation, Rayons ultraviolets, Stress oxydatif, Stress physiologique, Transduction du signal.
English descriptors
- KwdEn :
- Amino Acids (metabolism), Eukaryotic Initiation Factor-2 (metabolism), Oxidative Stress (MeSH), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (metabolism), Schizosaccharomyces (metabolism), Schizosaccharomyces pombe Proteins (metabolism), Signal Transduction (MeSH), Sirolimus (pharmacology), Starvation (metabolism), Stress, Physiological (MeSH), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (metabolism), Ultraviolet Rays (MeSH).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , metabolism : Amino Acids, Eukaryotic Initiation Factor-2, Protein-Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins, TOR Serine-Threonine Kinases.
- metabolism : Schizosaccharomyces, Starvation.
- chemical , pharmacology : Sirolimus.
- Oxidative Stress, Phosphorylation, Signal Transduction, Stress, Physiological, Ultraviolet Rays.
Abstract
Regulating growth and the cell cycle in response to environmental fluctuations is important for all organisms in order to maintain viability. Two major pathways for translational regulation are found in higher eukaryotes: the Tor signaling pathway and those operating through the eIF2α kinases. Studies from several organisms indicate that the two pathways are interlinked, in that Tor complex 1 (TORC1) negatively regulates the Gcn2 kinase. Furthermore, inactivation of TORC1 may be required for activation of Gcn2 in response to stress. Here, we use the model organism Schizosaccharomyces pombe to investigate this crosstalk further. We find that the relationship is more complex than previously thought. First, in response to UV irradiation and oxidative stress, Gcn2 is fully activated in the presence of TORC1 signaling. Second, during amino-acid starvation, activation of Gcn2 is dependent on Tor2 activity, and Gcn2 is required for timely inactivation of the Tor pathway. Our data show that the crosstalk between the two pathways varies with the actual stress applied.
DOI: 10.4161/cc.27270
PubMed: 24280780
PubMed Central: PMC3956541
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Two major pathways for translational regulation are found in higher eukaryotes: the Tor signaling pathway and those operating through the eIF2α kinases. Studies from several organisms indicate that the two pathways are interlinked, in that Tor complex 1 (TORC1) negatively regulates the Gcn2 kinase. Furthermore, inactivation of TORC1 may be required for activation of Gcn2 in response to stress. Here, we use the model organism Schizosaccharomyces pombe to investigate this crosstalk further. We find that the relationship is more complex than previously thought. First, in response to UV irradiation and oxidative stress, Gcn2 is fully activated in the presence of TORC1 signaling. Second, during amino-acid starvation, activation of Gcn2 is dependent on Tor2 activity, and Gcn2 is required for timely inactivation of the Tor pathway. Our data show that the crosstalk between the two pathways varies with the actual stress applied. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24280780</PMID><DateCompleted><Year>2015</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1551-4005</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>3</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Cell cycle (Georgetown, Tex.)</Title><ISOAbbreviation>Cell Cycle</ISOAbbreviation></Journal><ArticleTitle>Crosstalk between the Tor and Gcn2 pathways in response to different stresses.</ArticleTitle><Pagination><MedlinePgn>453-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4161/cc.27270</ELocationID><Abstract><AbstractText>Regulating growth and the cell cycle in response to environmental fluctuations is important for all organisms in order to maintain viability. Two major pathways for translational regulation are found in higher eukaryotes: the Tor signaling pathway and those operating through the eIF2α kinases. Studies from several organisms indicate that the two pathways are interlinked, in that Tor complex 1 (TORC1) negatively regulates the Gcn2 kinase. Furthermore, inactivation of TORC1 may be required for activation of Gcn2 in response to stress. Here, we use the model organism Schizosaccharomyces pombe to investigate this crosstalk further. We find that the relationship is more complex than previously thought. First, in response to UV irradiation and oxidative stress, Gcn2 is fully activated in the presence of TORC1 signaling. Second, during amino-acid starvation, activation of Gcn2 is dependent on Tor2 activity, and Gcn2 is required for timely inactivation of the Tor pathway. Our data show that the crosstalk between the two pathways varies with the actual stress applied. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rødland</LastName><ForeName>Gro Elise</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Department of Cell Biology; Institute for Cancer Research; Oslo University Hospital; Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tvegård</LastName><ForeName>Tonje</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cell Biology; Institute for Cancer Research; Oslo University Hospital; Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boye</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Cell Biology; Institute for Cancer Research; Oslo University Hospital; Oslo, Norway; Institute for Molecular Biosciences; University of Oslo; Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grallert</LastName><ForeName>Beáta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Cell Biology; Institute for Cancer Research; Oslo University Hospital; Oslo, Norway.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Cycle</MedlineTA><NlmUniqueID>101137841</NlmUniqueID><ISSNLinking>1551-4005</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000596">Amino Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015852">Eukaryotic Initiation Factor-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029702">Schizosaccharomyces pombe Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C539007">Gcn2 protein, S pombe</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000596" MajorTopicYN="N">Amino Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015852" MajorTopicYN="N">Eukaryotic Initiation Factor-2</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012568" MajorTopicYN="N">Schizosaccharomyces</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029702" MajorTopicYN="N">Schizosaccharomyces pombe Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013217" MajorTopicYN="N">Starvation</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="Y">Stress, Physiological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014466" MajorTopicYN="N">Ultraviolet Rays</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gcn2</Keyword><Keyword MajorTopicYN="N">S. pombe</Keyword><Keyword MajorTopicYN="N">Tor</Keyword><Keyword MajorTopicYN="N">UV irradiation</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">starvation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24280780</ArticleId><ArticleId IdType="pii">27270</ArticleId><ArticleId 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name="Norvège"><noRegion><name sortKey="R Dland, Gro Elise" sort="R Dland, Gro Elise" uniqKey="R Dland G" first="Gro Elise" last="R Dland">Gro Elise R Dland</name></noRegion><name sortKey="Boye, Erik" sort="Boye, Erik" uniqKey="Boye E" first="Erik" last="Boye">Erik Boye</name><name sortKey="Grallert, Beata" sort="Grallert, Beata" uniqKey="Grallert B" first="Beáta" last="Grallert">Beáta Grallert</name><name sortKey="Tveg Rd, Tonje" sort="Tveg Rd, Tonje" uniqKey="Tveg Rd T" first="Tonje" last="Tveg Rd">Tonje Tveg Rd</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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